TATA-binding protein (TBP) subunit of TFIID to the TATA box element, which nucleates assembly of TFIIA and TFIIB, followed by assembly of TFIIF and Pol II as a pre-assembled complex, and culminating in assembly of TFIIE and TFIIH
نویسندگان
چکیده
Animal growth and development depend on the precise control of gene expression at the level of transcription. A central role in the regulation of developmental transcription is attributed to transcription factors that bind DNA enhancer elements, which are often located far from gene transcription start sites. Here, we review recent studies that have uncovered significant regulatory functions in developmental transcription for the TFIID basal transcription factors and for the DNA core promoter elements that are located close to transcription start sites.
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